Even in the third decade of the twenty-first century, it is still harder for women to make a career in science than men. Two centuries ago, however, at the beginning of the nineteenth century, when science as we know it was just getting started, the situation was far worse. Then, the very notion of a female scientist would have been regarded as something of an oxymoron. From bestselling and award-winning science writers John and Mary Gribbin, Against the Odds highlights the achievements of women who overcame hurdles and achieved scientific success (although not always as much as they deserved) in spite of male prejudice, as society changed over about 150 years, from the middle of the nineteenth century to the end of the twentieth century. There is Eunice Newton Foote, who discovered the carbon dioxide greenhouse effect, Chien-Shiung Wu, who discovered the law which allows matter to exist in the Universe today, and Barbara McClintock, who discovered how genes turn on and off. With a foreword from astrophysicist Jocelyn Bell Burnell, this book is not only a cautionary tale about the stifling effects of prejudice against women in science, but is a celebration of those who achieved success against the odds - and an inspiration for the next generation.