John Milton has been off the grid for six months. He surfaces in Ciudad Juarez, Mexico, and immediately finds himself drawn into a vicious battle with the narco-gangs that control the borderlands. Milton saves the life of an idealistic young journalist who has been targeted for execution but the only way to keep her safe is to smuggle her into Texas. Working with the only untouchable cops in the city, and a bounty hunter whose motives are unclear, Milton must keep her safe until the crossing can be made. But when the man looking for her is the legendary assassin Santa Muerta - Saint Death - that's a lot easier said than done...